PARP-1/Proteasome-IN-1
PARP-1/Proteasome-IN-1 (compound 42i) is a dual PARP-1 and proteasome inhibitor with significant inhibitory effects on breast cancer. PARP-1/Proteasome-IN-1 can downregulate the expression of BRCA1 and RAD51 to inhibit homologous recombination repair function and induce apoptosis[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; PARP; Proteasome
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp-1-proteasome-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCSC)C(N[C@H](B1O[C@@](C[C@H]2C(C)(C)[C@@H]3C2)(C)[C@@]3([H])O1)CC(C)C)=O)C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F
Molecular Formula
C36H46BFN4O5S
Molecular Weight
676.65
References & Citations
[1]He H et al. Design and synthesis of the first PARP-1 and proteasome dual inhibitors to treat breast cancer[J]. European Journal of Medicinal Chemistry, 2023: 115943.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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