Anti-inflammatory agent 66

Anti-inflammatory agent 66 (compound 8) is a pterostilbene derivative with anti-inflammatory activity. Anti-inflammatory agent 66 inhibits pro-inflammatory cytokines by blocking the LPS-induced NF-κB/MAPK signaling pathway and effectively alleviates DSS-induced acute colitis in mice[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

NF-κB; p38 MAPK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-66.html

Solubility

10 mM in DMSO

Smiles

C=CCOC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2C3=CN=NN3C(NCCCl)=O)C=C1

Molecular Formula

C24H25ClN4O4

Molecular Weight

468.93

References & Citations

[1]Chen L et al. Design and synthesis of pterostilbene derivatives bearing triazole moiety that might treat DSS-induced colitis in mice through modulation of NF-κB/MAPK signaling pathways. Eur J Med Chem. 2023 Nov 17;263:115949.