TrkA-IN-6
Product Specifications
UNSPSC Description
TrkA-IN-6 (compound R48) is a hydrazone-like, selective inhibitor of tropomyosin kinase type A receptor kinase (TrkA). TrkA-IN-6 exhibited a higher cytotoxic effect on U87 GBM cells than Temozolomide (HY-17364), with an IC50 of 68.99 μM[1].
Target Antigen
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling;Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trka-in-6.html
Solubility
10 mM in DMSO
Smiles
CC(/C(C(C1=CC=CC=C1)=O)=N\NC2=CC=C([N+]([O-])=O)C=C2O)=O
Molecular Weight
327.29
References & Citations
[1]Murugesan A et al. Design, synthesis and anticancer evaluation of novel arylhydrazones of active methylene compounds. Int J Biol Macromol. 2023 Nov 10;254(Pt 3):127909.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157168/TrkA-IN-6-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157168/
Clinical Information
No Development Reported
Curated Selection
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