TrkA-IN-6

TrkA-IN-6 (compound R48) is a hydrazone-like, selective inhibitor of tropomyosin kinase type A receptor kinase (TrkA) . TrkA-IN-6 exhibited a higher cytotoxic effect on U87 GBM cells than Temozolomide (HY-17364), with an IC50 of 68.99 μM[1].

Product Specifications

UNSPSC

12352005

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trka-in-6.html

Solubility

10 mM in DMSO

Smiles

CC(/C(C(C1=CC=CC=C1)=O)=N\NC2=CC=C([N+]([O-])=O)C=C2O)=O

Molecular Formula

C16H13N3O5

Molecular Weight

327.29

References & Citations

[1]Murugesan A et al. Design, synthesis and anticancer evaluation of novel arylhydrazones of active methylene compounds. Int J Biol Macromol. 2023 Nov 10;254 (Pt 3) :127909.