Tubulin/PARP-IN-1

Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase[1].

Product Specifications

UNSPSC

12352005

Target

Microtubule/Tubulin; PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-parp-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(OC2=C1C=CC(C3=COC=C3)=C2)C4C=CC(F)=CC4

Molecular Formula

C19H13FO3

Molecular Weight

308.30

References & Citations

[1]Sharma S et al. Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2276665.