Tubulin/PARP-IN-1
Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase[1].
Product Specifications
UNSPSC
12352005
Target
Microtubule/Tubulin; PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-parp-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(OC2=C1C=CC(C3=COC=C3)=C2)C4C=CC(F)=CC4
Molecular Formula
C19H13FO3
Molecular Weight
308.30
References & Citations
[1]Sharma S et al. Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2276665.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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