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BTK-IN-28

BTK-IN-28 (compound PID-4) is a potent BTK inhibitor with anticancer activity. BTK-IN-28 has inhibitory effects on BTK and downstream signaling cascades and selectively inhibits Burkitt lymphoma RAMOS proliferation. BTK-IN-28 has no significant cytotoxicity towards non-tumor cells[1].

Product Specifications

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/btk-in-28.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC2=C(NC(/C2=C3CCOCC\3)=O)C=C1)(NC4=CC=C(C)C=C4)=O

Molecular Formula

C20H20N2O4S

Molecular Weight

384.45

References & Citations

[1]Koraboina CP et al. Synthesis and Biological Evaluation of Oxindole Sulfonamide Derivatives as Bruton's Tyrosine Kinase Inhibitors. ChemMedChem. 2023 Nov 2:e202300511.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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