TrxR-IN-6

TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis[1].

Product Specifications

CAS Number

[3032446-53-7]

UNSPSC

12352005

Target

Apoptosis; TrxR

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/trxr-in-6.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C([As]2SCCCS2)C=C1)C(Cl)Cl

Molecular Formula

C11H12AsCl2NOS2

Molecular Weight

384.18

References & Citations

[1]She W et al. Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy. Biochem Pharmacol. 2023 Nov 4;218:115908.