PAD4-IN-3
Product Specifications
UNSPSC Description
PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment[1].
Target Antigen
Protein Arginine Deiminase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/pad4-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CC=CC=C1)[C@H](CCCNC(CCl)=N)NC(C2=CC(B(O)O)=CC=C2)=O
Molecular Weight
444.72
References & Citations
[1]Jia Y et al. Chitosan nanomedicine containing RGD peptide and PAD4 inhibitor based on phenyl boronate coupling inhibition of primary tumor growth and lung metastasis. Biomed Pharmacother. 2023 Dec;168:115826.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157157/PAD4-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157157/
Clinical Information
No Development Reported
CAS Number
2642327-44-2
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