HDAC-IN-65
HDAC-IN-65 (compound 6) is a selective histone deacetylase (HDAC) inhibitor with IC50 value of 2.5μM. HDAC-IN-65 is a prodrug with very good bioreductive properties[1].
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-65.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC=C1NC(C2=NC=C(N=C2)N3CCN(CC3)CC4=CNC5=C4C=CC=C5)=O)OCC6=CN=C(N6C)[N+]([O-])=O
Molecular Formula
C30H30N10O5
Molecular Weight
610.62
References & Citations
[1]Mohamed Abdelsalam, et al. Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells. Arch Pharm (Weinheim) . 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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