MMP-9-IN-8

MMP-9-IN-8 (Compound 3) is an MMP-9 inhibitor with inhibitory activities of 42.16% and 58.28% at 10 μM and 50 μM concentrations, respectively. MMP-9-IN-8 has anti-cancer activity and can induce apoptosis in MCF-7 cells with an IC50 value of 23.42 μM[1].

Product Specifications

CAS Number

[2490543-89-8]

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mmp-9-in-8.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(C(C(F)(F)F)=C1)F)NC2=NC(N3CCN(CC3)C)=C(C=CN4C)C4=N2

Molecular Formula

C20H21F4N7O

Molecular Weight

451.42

References & Citations

[1]Kilic-Kurt Z, et al. Effects of pyrrolopyrimidine derivatives on cancer cells cultured in vitro and potential mechanism. Naunyn Schmiedebergs Arch Pharmacol. 2023 Oct 28.