PARP1-IN-17
PARP1-IN-17 is a PARP-1 inhibitor (IC50 = 19.24 nM for PARP-1 and = 32.58 nM for PARP-2) and induce apoptosis. PARP1-IN-17 shows excellent anti-proliferative activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Caspase; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp1-in-17.html
Solubility
10 mM in DMSO
Smiles
OC1C2=CC=CC=C2C3(CCCCC3)N(CC4=CN(C5=CC=CC=C5F)N=N4)CC1
Molecular Formula
C24H27FN4O
Molecular Weight
406.50
References & Citations
[1]Yu L, et al. Discovery of novel 2, 3, 4, 5-tetrahydrospiro [benzo [c] azepine-1, 1’-cyclohexan]-5-ol derivatives as PARP-1 inhibitors [J]. BMC chemistry, 2023, 17 (1) : 147.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; PARP1
Curated Selection
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