HCAIX-IN-19
HCAIX-IN-19 is a sulfonamides inhibitor against hCA IX with an inhibition constant (KI) of 6.2 nM and show good selectivity over hCA I (hCA I/ hCA IX = 117) [1].
Product Specifications
UNSPSC
12352005
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hcaix-in-19.html
Solubility
10 mM in DMSO
Smiles
O=C1N[C@@]2([H])[C@@](CS[C@H]2CCCCC(N(CC3=CC=C(C=CC=C4)C4=C3)CCC5=CC=C(S(=O)(N)=O)C=C5)=O)([H])N1
Molecular Formula
C29H34N4O4S2
Molecular Weight
566.73
References & Citations
[1]Begines P, et al. Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies [J]. Bioorganic & Medicinal Chemistry, 2023, 94: 117467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA IX
Frequently Asked Questions
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