HCAIX-IN-19

HCAIX-IN-19 is a sulfonamides inhibitor against hCA IX with an inhibition constant (KI) of 6.2 nM and show good selectivity over hCA I (hCA I/ hCA IX = 117) [1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hcaix-in-19.html

Solubility

10 mM in DMSO

Smiles

O=C1N[C@@]2([H])[C@@](CS[C@H]2CCCCC(N(CC3=CC=C(C=CC=C4)C4=C3)CCC5=CC=C(S(=O)(N)=O)C=C5)=O)([H])N1

Molecular Formula

C29H34N4O4S2

Molecular Weight

566.73

References & Citations

[1]Begines P, et al. Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies [J]. Bioorganic & Medicinal Chemistry, 2023, 94: 117467.