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JAK-IN-34

JAK-IN-34 (compound 11n) is a potent against of JAKs with IC50 values of 0.40, 0.83, 2.10, 1.95 nM target JAK1, JAK2, JAK3, TYK2, respectively. JAK-IN-34 reduces joint swelling with good safety[1].

Product Specifications

CAS Number

2068766-90-3

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jak-in-34.html

Solubility

10 mM in DMSO

Smiles

N#CCOC1=CC=C(C2=CC=CC3=C2N=C(NC4=CC=CC(N5CCN(CC5)C)=C4)N=C3)C=C1

Molecular Formula

C27H26N6O

Molecular Weight

450.53

References & Citations

[1]Jinbao Xiang, et al. Design, synthesis, and pharmacological evaluation of quinazoline derivatives as novel and potent pan-JAK inhibitors. Bioorg Chem. 2023.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JAK1; JAK2; JAK3; Tyk2

Frequently Asked Questions

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