AChE/MAO-B-IN-4

AChE/MAO-B-IN-4 (compound 4a) is a selective dual AChE and MAO-B inhibitor. AChE/MAO-B-IN-4 shows no significant inhibition activity against BChE and h-MAO-A. AChE/MAO-B-IN-4 can be used for the Alzheimer’s disease (AD) research[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-mao-b-in-4.html

Solubility

10 mM in DMSO

Smiles

CC(N1CCN(C2=NC=CC=N2)CC1)C(NC3=NN=C(S3)C45C[C@H](C6)C[C@@H](C5)C[C@H]6C4)=O

Molecular Formula

C23H31N7OS

Molecular Weight

453.60

References & Citations

[1]Amal A Al-Sharabi, et al. Synthesis, characterization, molecular docking and molecular dynamics simulations of novel 2,5-disubstituted-1,3,4-thiadiazole derivatives as potential cholinesterase/monoamine oxidase dual inhibitors for Alzheimer's disease. J Biomol Struct Dyn. 2023 Nov 1:1-19.