HS-291

HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb) . HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin) .HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; ROS Kinase

Type

Reference compound

Related Pathways

Anti-infection; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hs-291.html

Solubility

10 mM in DMSO

Smiles

O=C(CCC1=C(N2)/C=C3C(CCC(OC)=O)=C(C)C(/C=C4N/C(C(C)=C\4C=C)=C\C(C5=CC=C([C@H]([C@]5/6C)C(OC)=O)C(OC)=O)=NC6=C/C2=C1C)=N/3)NCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC7=CC=C(N8C(NN=C8C9=C(O)C=C(O)C(C(C)C)=C9)=S)C=C7)=O.CC(CCC%10=C%11NC(/C=C(N=C(/C=C(N/C%12=C\C(C(C)=C/%13CCC(ONCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC(C=C%14)=CC=C%14N%15C(C(C=C(C(O)=C%16)C(C)C)=C%16O)=NNC%15=S)=O)=O)=NC%13=C/%11)/C(C)=C%12C=C)C%17=CC=C(C(OC)=O)[C@H]%18C(OC)=O)/[C@@]%17%18C)=C%10C)=O

Molecular Formula

C156H194N18O36S2

Molecular Weight

2961.44

References & Citations

[1]Carlson DL, et al. Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development. Cell Chem Biol. 2023 Nov 1:S2451-9456 (23) 00340-9.