MCMY020

MCMY020 is a covalent inhibitor of TEAD. mCMY020 effectively reduces YAP (Yes-associated protein) -driven transcription and selectively slows the proliferation of Hippo-deficient cancer cells. mCMY020 can be used in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mcmy020.html

Solubility

10 mM in DMSO

Smiles

C=C(C(NC1=C2N=C(C=CN2N=C1)C3=CC=C(C=C3)C4CCCCC4)=O)F

Molecular Formula

C21H21FN4O

Molecular Weight

364.42

References & Citations

[1]Nutsch K, et al. A covalent inhibitor of the YAP-TEAD transcriptional complex identified by high-throughput screening. RSC Chem Biol. 2023 Aug 29;4 (11) :894-905.