ZHSI-1

ZHSI-1 is an EV71 (Enterovirus 71) inhibitor that inhibits EV71/CVA16 replication and virus-induced pyroptosis associated with viral pathogenesis. ZHSI-1 effectively prevents EV71 infection in neonatal and young mice in animal models. ZHSI-1 can be used to study viral infections such as hand, foot and mouth disease (HFMD) [1].

Product Specifications

CAS Number

[2925912-67-8]

UNSPSC

12352005

Target

Enterovirus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/zhsi-1.html

Solubility

10 mM in DMSO

Smiles

CC(NC1=NC(NC2=CC=C3C(C=CC=N3)=C2)=CC(C)=N1)C

Molecular Formula

C17H19N5

Molecular Weight

293.37

References & Citations

[1]Wang X, et al. Inhibition of lysosome-tethered Ragulator-Rag-3D complex restricts the replication of Enterovirus 71 and Coxsackie A16. J Cell Biol. 2023 Dec 4;222 (12) :e202303108.