Sulcardine
Sulcardine is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine has anti-arrhythmic effects[1][2].
Product Specifications
CAS Number
343935-60-4
UNSPSC
12352005
Target
Calcium Channel; Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sulcardine.html
Solubility
10 mM in DMSO
Smiles
O=S(NCC1=CC(CN2CCCC2)=C(O)C(CN3CCCC3)=C1)(C4=CC=C(C=C4)OC)=O
Molecular Formula
C24H33N3O4S
Molecular Weight
459.60
References & Citations
[1]Bai DL, et al. Discovery of N- (3,5-bis (1-pyrrolidylmethyl) -4-hydroxybenzyl) -4-methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent. Acta Pharmacol Sin. 2012 Sep;33 (9) :1176-86.|[2]Chen W, et al. Characteristics of hERG and hNav1.5 channel blockade by sulcardine sulfate, a novel anti-arrhythmic compound. Eur J Pharmacol. 2019 Feb 5;844:130-138.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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