JNJ-40929837 (succinate)
JNJ-40929837 succinate is a selective and orally active LTA4H (leukotriene A4 hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research[1].
Product Specifications
CAS Number
[1191044-47-9]
UNSPSC
12352005
Target
Aminopeptidase; Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jnj-40929837-succinate.html
Solubility
10 mM in DMSO
Smiles
OC(CCC(O)=O)=O.CC(N[C@@H](C[C@@]1([H])CC2)C[C@@]2([H])N1CC3=CC=C(C=C3)OC4=NC5=NC=CC=C5S4)=O.[x]
Molecular Formula
C22H24N4O2S.xC4H6O4
References & Citations
[1]Low CM, et al. The development of novel LTA4H modulators to selectively target LTB4 generation. Sci Rep. 2017 Mar 17;7:44449.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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