Tyrosine kinase-IN-7
Product Specifications
UNSPSC Description
Tyrosine kinase-IN-7 (compound 13h) is an inhibitor of the tyrosine kinase EGFR. The IC50s for inhibiting EGFR(WT) and EGFR(T790M) are 0.630 μM and 0.956 μM respectively. Tyrosine kinase-IN-7 has antitumor activity against four cancer cell lines (HepG2, HCT-116, MCF-7, and A431) with IC50s of 13.02 μM, 10.14 μM, 12.68 μM, and 47.05 μM, respectively[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/tyrosine-kinase-in-7.html
Purity
99.25
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC1=CC=C(NC2=C3C(CCCC4)=C4SC3=NC=N2)C=C1
Molecular Weight
297.37
References & Citations
[1]Elmetwally SA, et al. Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers. Bioorg Chem. 2019 Jul;88:102944.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156912/Tyrosine-kinase-IN-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156912/Tyrosine-kinase-IN-7-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
345615-74-9
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