SGC-NSP2PRO-1
SGC-NSP2PRO-1 is a potent irreversible covalent inhibitor of Chikungunya (CHIKV) nsP2 cysteine protease with an IC50 value of 60 nM. SGC-NSP2PRO-1 demonstrates potent antialphavirus activity, inhibiting CHIKV and VEEV replication with EC50 = 0.01 and 0.3 µM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
CHIKV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nsp2-protease-in-1.html
Smiles
CCOC1=CC=CC=C1C2=NOC(C(NC/C=C/S(=O)(C)=O)=O)=C2
Molecular Formula
C16H18N2O5S
Molecular Weight
350.39
References & Citations
[1]Ghoshal A, et al. Structure Activity of β-Amidomethyl Vinyl Sulfones as Covalent Inhibitors of Chikungunya nsP2 Cysteine Protease with Anti-alphavirus Activity. bioRxiv [Preprint]. 2024 Jun 13:2024.06.12.598722.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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