Antiproliferative agent-39

Antiproliferative agent-39 (Compound 12) inhibits proliferation of A549, SNU-638, Col2, HT1080, MCF-7 with IC50s of 11, 25, 14, 11, 6.3 μM respectively[1].

Product Specifications

CAS Number

[871837-61-5]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antiproliferative-agent-39.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=C(/C1=C3NC4=C(C/3=N\O)C=CC=C4)C=C(NC(CC(C)(C)C)=O)C=C2

Molecular Formula

C22H22N4O3

Molecular Weight

390.44

References & Citations

[1]Moon MJ, et al. Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities. Bioorg Med Chem. 2006 Jan 1;14 (1) :237-46.