NSC309401 (dihydrochloride)

NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM) [1].

Product Specifications

CAS Number

[77681-42-6]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nsc309401-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

NC(C=C1)=CC=C1CN2C=CC3=C4C(N=C(N)N=C4N)=CC=C32.Cl.Cl

Molecular Formula

C17H18Cl2N6

Molecular Weight

377.27

References & Citations

[1]Srinivasan B, et al. Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors. FEBS J. 2015 May;282 (10) :1922-38.