NSC309401 (dihydrochloride)
NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM) [1].
Product Specifications
CAS Number
[77681-42-6]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nsc309401-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
NC(C=C1)=CC=C1CN2C=CC3=C4C(N=C(N)N=C4N)=CC=C32.Cl.Cl
Molecular Formula
C17H18Cl2N6
Molecular Weight
377.27
References & Citations
[1]Srinivasan B, et al. Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors. FEBS J. 2015 May;282 (10) :1922-38.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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