HLDA-221
HLDA-221 is a heterobifunctional small molecules called Regulated Induced Proximity Targeting Chimeras (RIPTACs) . HLDA-221 elicits a stable ternary complex between a target protein selectively expressed in cancer tissue and a pan-expressed protein essential for cell survival, thus leading to cell death selectively in cells expressing the target protein[1].
Product Specifications
CAS Number
3077339-82-0
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hlda-221.html
Concentration
10mM
Purity
99.24
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CC(C(C(C(C=C1)=CC=C1Cl)=N[C@H]2CC(NCCOCCOCCN(C(COC3=CC=CC([C@@H](CCC4=CC(OC)=C(OC)C=C4)OC([C@@H]5CCCCN5C([C@H](C6=CC(OC)=C(OC)C(OC)=C6)CC)=O)=O)=C3)=O)C)=O)=C(S7)N8C2=NN=C8C)=C7C
Molecular Formula
C64H78ClN7O13S
Molecular Weight
1220.86
References & Citations
[1]Kanak Raina, et al. Regulated Induced Proximity Targeting Chimeras (RIPTACs) : a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively. bioRxiv. 2023 Jan 2:2023.01.01.522436.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PR1001-R-S 1 Each
Accuris Taq Master Mix Red Dye, 2X conc., sample, 5 reactions
Sign In for Pricing
View Details 
![HABP2 Mouse Monoclonal Antibody [Clone ID: OTI2B5]](https://cdn.genprice.uk/products/937/68dd18ba061270361e908594/imageurl/cf809360.webp)
![GBP1 Rabbit Monoclonal Antibody [Clone ID: R02-7B6]](https://cdn.genprice.uk/products/937/68dd1b60061270361ea12391/imageurl/ta421736.webp)
TA421736 100 µL
GBP1 Rabbit Monoclonal Antibody [Clone ID: R02-7B6]
Sign In for Pricing
View Details