Cholesterol 24-hydroxylase-IN-2

Cholesterol 24-hydroxylase-IN-2 is an inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1), with the IC50 of 5.4 nM. Cholesterol 24-hydroxylase-IN-2 can be used in imaging of cholesterol 24-hydroxylase in mammals[1].

Product Specifications

CAS Number

[1613481-52-9]

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cholesterol-24-hydroxylase-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(C1CCN(CC1)C2=C(C3=CC=C(F)C=C3)N=CN=C2)N(C4CC4)C

Molecular Formula

C20H23FN4O

Molecular Weight

354.42

References & Citations

[1]Koike Tatsuki, et al. Preparation of arylpiperidines and arylpiperazines as radiolabeled compounds for use in imaging of cholesterol 24-hydroxylase. World Intellectual Property Organization, WO2015190613 A1 2015-12-17