Akt/ROCK-IN-1

Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively. Akt/ROCK-IN-1 has antitumor activity for neuroblastoma[1].

Product Specifications

CAS Number

[2983889-44-5]

UNSPSC

12352005

Target

ADC Payload

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/akt-rock-in-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C(S1)=CC2=C1OCCN3C2=C(Br)C=N3)N[C@@H]4CNCC[C@H]4C5=CC=C(F)C(F)=C5

Molecular Formula

C21H19BrF2N4O2S

Molecular Weight

509.37

References & Citations

[1]Jinxin Che, et al. Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment. J Med Chem. 2023 Oct 12;66 (19) :13530-13555.