Akt/ROCK-IN-1
Product Specifications
UNSPSC Description
Akt/ROCK-IN-1 (B12) is a dual inhibitor for Akt and ROCK, with the IC50s of 0.023 nM and 1.47 nM, respectively. Akt/ROCK-IN-1 has antitumor activity for neuroblastoma[1].
Target Antigen
ADC Cytotoxin
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/akt-rock-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C(S1)=CC2=C1OCCN3C2=C(Br)C=N3)N[C@@H]4CNCC[C@H]4C5=CC=C(F)C(F)=C5
Molecular Weight
509.37
References & Citations
[1]Jinxin Che, et al. Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment. J Med Chem. 2023 Oct 12;66(19):13530-13555.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156796/Akt-ROCK-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156796/
Clinical Information
No Development Reported
CAS Number
2983889-44-5
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