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Cbl-b-IN-11

Cbl-b-IN-11 (Compound 466) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 6.4 nM and 6.1 nM, respectively[1].

Product Specifications

CAS Number

2815225-15-9

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cbl-b-in-11.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(CN1C3=CC(NCC)=CC(C4(CC(F)(C4)F)CC5=NN=CN5C)=C3)C(C(F)(F)F)=CC(CNC6(CCC6)C)=C2

Molecular Formula

C31H35F5N6O

Molecular Weight

602.64

References & Citations

[1]Jun Liang, et al. Lactams as cbl-b inhibitors. Patent WO2022169997A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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