Cbl-b-IN-8
Cbl-b-IN-8 (Compound 293) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 5.5 nM and 7.8 nM, respectively[1].
Product Specifications
CAS Number
2815223-33-5
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbl-b-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC(CN3[C@H](CN(CC3)C)C(C)C)=CC(C(F)(F)F)=C2CN1C4=CC(C5(COC5)CC6=NN=CN6C)=CC(OC7CCCC7)=N4
Molecular Formula
C35H44F3N7O3
Molecular Weight
667.76
References & Citations
[1]Jun Liang, et al. Lactams as cbl-b inhibitors. Patent WO2022169997A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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