Cbl-b-IN-7
Cbl-b-IN-7 (Compound 248) is a casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl inhibitor with IC50s of 6.7 nM and 5.2 nM, respectively[1].
Product Specifications
CAS Number
[2815221-35-1]
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbl-b-in-7.html
Solubility
10 mM in DMSO
Smiles
F[C@@H](C1=NN=CN1C)C2(C3=CC(N4CC5=C(C(F)(F)F)C=C([C@H](C)NC6(CCC6)C)C=C5C4=O)=CC=C3)COC2
Molecular Formula
C29H31F4N5O2
Molecular Weight
557.58
References & Citations
[1]Jun Liang, et al. Lactams as cbl-b inhibitors. Patent WO2022169997A1.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156763/Cbl-b-IN-7-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156763/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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