METTL3-IN-5
METTL3-IN-5 (Compound 13) is a METTL3 inhibitor. METTL3-IN-5 inhibits MOLM-13 growth with an IC50 less than 2 μM. METTL3-IN-5 has weak hERG inhibitory activity (IC50 >30 μM) . METTL3-IN-5 can be used for AML research[1].
Product Specifications
CAS Number
[2965311-25-3]
UNSPSC
12352005
Target
METTL3
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mettl3-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C(C(NCC2=CC3=C(C=C(CNCC45CC(C4)(C5)F)N3)S2)=O)N=C6C=CC=CN16
Molecular Formula
C23H22FN5O2S
Molecular Weight
451.52
References & Citations
[1]Zhong Chen, et al. Mettl3 inhibitor and composition, and application of same in medicine. WO2023151697 A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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