METTL3-IN-5

METTL3-IN-5 (Compound 13) is a METTL3 inhibitor. METTL3-IN-5 inhibits MOLM-13 growth with an IC50 less than 2 μM. METTL3-IN-5 has weak hERG inhibitory activity (IC50 >30 μM) . METTL3-IN-5 can be used for AML research[1].

Product Specifications

CAS Number

[2965311-25-3]

UNSPSC

12352005

Target

METTL3

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mettl3-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C(NCC2=CC3=C(C=C(CNCC45CC(C4)(C5)F)N3)S2)=O)N=C6C=CC=CN16

Molecular Formula

C23H22FN5O2S

Molecular Weight

451.52

References & Citations

[1]Zhong Chen, et al. Mettl3 inhibitor and composition, and application of same in medicine. WO2023151697 A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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