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3β-Hydroxy-lup-20 (29) -en-16-one

3β-Hydroxy-lup-20 (29) -en-16-one (compound 9) is a dual inhibitor of AChE and BChE, with selectivity for BChE (IC50: 28.9 μM) [1].

Product Specifications

CAS Number

[65043-60-9]

UNSPSC

12352211

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/3β-hydroxy-lup-20-29-en-16-one.html

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O)C)([H])CC2)C)([H])[C@]5([H])[C@@](C(C3)=O)(CC[C@H]5C(C)=C)C)C

Molecular Formula

C30H48O2

Molecular Weight

440.70

References & Citations

[1]Castro MJ, et al. Oxidation at C-16 enhances butyrylcholinesterase inhibition in lupane triterpenoids. Bioorg Chem. 2018 Sep;79:301-309.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

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