(Rac) -GDC-2992
(Rac) -GDC-2992 (Compound 1) is a PROTAC androgen receptor degrader (DC50: 10 nM in VCaP cell) . (Rac) -GDC-2992 blocks the process of androgen receptor transduction and also degrades the receptor itself. (Rac) -GDC-2992 can be used for prostate cancer research. Pink: AR ligand (HY-130845) ; Blue: E3 ligase ligand (HY-W1003189) ; Black: linker (HY-169975) [1].
Product Specifications
CAS Number
[2753650-84-7]
Product Name Alternative
(Rac) -RO7656594; PROTAC AR Degrader-6
UNSPSC
12352005
Target
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/androgen-receptor-degrader-3.html
Purity
95.00
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC(C)([C@H](C1(C)C)NC(C2=CC=C(N3CCC(CC3)CN4CCN(C5=CC=C(C(N(C6C(NC(CC6)=O)=O)N=C7)=O)C7=C5)CC4)C=C2)=O)[C@H]1OC8=CC(Cl)=C(C=C8)C#N
Molecular Formula
C45H51ClN8O5
Molecular Weight
819.39
References & Citations
[1]Lu H.F, et al. . China, WO2021249534 A1.2021-12-16.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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