DBt-10

DBt-10 is a potent BTK PROTAC degrader (DC50: 137 nM) . Blue: DCAF1 binder (HY-149934) ; Black: linker; Pink: BTK ligand[1].

Product Specifications

UNSPSC

12352005

Target

Btk; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbt-10.html

Solubility

10 mM in DMSO

Smiles

ClC(C=C1)=CC=C1C2(CCCCC2)C3=NC4=CC(N5CCN(C(CCCC(NCCN6CC7(CCN(C(CN8C=C(C9=CC(C(C%10=C(C)C(NC(N%11CC(CC(C)(C)C)(O)C%11)=O)=CC(F)=C%10)=NC=N%12)=C%12N9)C=N8)=O)CC7)OCC6)=O)=O)CC5)=CC=C4C(NCCN)=N3

Molecular Formula

C68H86ClFN16O6

Molecular Weight

1277.97

References & Citations

[1]Martin Schröder, et al. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance. Nat Commun. 2024 Jan 4;15 (1) :275.