DBt-10
Product Specifications
UNSPSC Description
DBt-10 is a potent BTK PROTAC degrader (DC50: 137 nM). Blue: DCAF1 binder (HY-149934); Black: linker; Pink: BTK ligand[1].
Target Antigen
Btk; PROTACs
Type
Reference compound
Related Pathways
PROTAC;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbt-10.html
Solubility
10 mM in DMSO
Smiles
ClC(C=C1)=CC=C1C2(CCCCC2)C3=NC4=CC(N5CCN(C(CCCC(NCCN6CC7(CCN(C(CN8C=C(C9=CC(C(C%10=C(C)C(NC(N%11CC(CC(C)(C)C)(O)C%11)=O)=CC(F)=C%10)=NC=N%12)=C%12N9)C=N8)=O)CC7)OCC6)=O)=O)CC5)=CC=C4C(NCCN)=N3
Molecular Weight
1277.97
References & Citations
[1]Martin Schröder, et al. DCAF1-based PROTACs with activity against clinically validated targets overcoming intrinsic- and acquired-degrader resistance. Nat Commun. 2024 Jan 4;15(1):275.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156746/DBt-10-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156746/
Clinical Information
No Development Reported
Curated Selection
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