D-4-77
D-4-77 is a potent inhibitor of SARS-CoV-2 Mpro with an IC50 value of 0.95 μM. D-4-77 has antiviral active with an EC50 value of 0.49 μM. D-4-77 suppresses SARS-CoV-2 Mpro -induced antagonism of the host NF-κB innate immune response[1].
Product Specifications
UNSPSC
12352005
Target
SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/d-4-77.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C[C@@H](C(OC)=O)NC([C@@H](NC([C@@H](NC(CBr)=O)C)=O)[C@@H](C)CC)=O)C(C)=C1
Molecular Formula
C23H34BrN3O5
Molecular Weight
512.44
References & Citations
[1]Liu M, et, al. The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors. Angew Chem Int Ed Engl. 2023 Aug 23:e202309657.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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Reference 2 Pack 3 100-1000uL; 0.5-5mL; 1-10mL pipettes
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