JAK-IN-31
JAK-IN-31 (Example 75) is a JAK inhibitor with IC50 ranges of ≤0.01µM, ≤0.01µM, 0.01-0.1 µM and ≤0.01µM for JAK1, JAK2, JAK3 and Tyk2 respectively. JAK-IN-31 can be used in cancer research[1].
Product Specifications
CAS Number
2597016-88-9
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak-in-31.html
Solubility
10 mM in DMSO
Smiles
CC1=NN=C(S1)C2=CN=C3C(C=CN3)=C2N[C@@H]4C[C@@H](C4)NS(=O)(C5=CC(C#N)=CC=C5)=O
Molecular Formula
C21H19N7O2S2
Molecular Weight
465.55
References & Citations
[1]David Randolph ANDERSON, et al. Substituted sulfonamide pyrrolopyridines as jak inhibitors. Patent WO2021022178A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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