TIE-2/VEGFR-2 kinase-IN-5

TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent TIE-2 and VEGFR-2 tyrosine kinase inhibitor with pIC50 values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis[1].

Product Specifications

CAS Number

[1014407-83-0]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Tie; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tie-2-vegfr-2-kinase-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)NC2=CC=C(C3=COC4=NC=NC(N)=C43)C=C2

Molecular Formula

C21H13F6N5O2

Molecular Weight

481.35

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Miyazaki Y, et al. Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 2007 Mar 15;17 (6) :1773-8.