TIE-2/VEGFR-2 kinase-IN-3
TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis[1].
Product Specifications
CAS Number
[433224-09-0]
UNSPSC
12352005
Target
Tie; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tie-2-vegfr-2-kinase-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC2=C(N1)C=C(SC3=CC=C(NC(NC4=CC(C(F)(F)F)=CC=C4F)=O)C=C3)C=C2)OC
Molecular Formula
C23H17F4N5O3S
Molecular Weight
519.47
References & Citations
[1]Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50 (18) :4453-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tie2; VEGFR2/KDR/Flk-1
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