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TIE-2/VEGFR-2 kinase-IN-3

TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis[1].

Product Specifications

CAS Number

[433224-09-0]

UNSPSC

12352005

Target

Tie; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tie-2-vegfr-2-kinase-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=NC2=C(N1)C=C(SC3=CC=C(NC(NC4=CC(C(F)(F)F)=CC=C4F)=O)C=C3)C=C2)OC

Molecular Formula

C23H17F4N5O3S

Molecular Weight

519.47

References & Citations

[1]Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50 (18) :4453-70.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Tie2; VEGFR2/KDR/Flk-1

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