TIE-2/VEGFR-2 kinase-IN-3
Product Specifications
UNSPSC Description
TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent TIE-2 and VEGFR-2 tyrosine kinase receptors inhibitors with IC50 values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis[1].
Target Antigen
Tie; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/tie-2-vegfr-2-kinase-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=NC2=C(N1)C=C(SC3=CC=C(NC(NC4=CC(C(F)(F)F)=CC=C4F)=O)C=C3)C=C2)OC
Molecular Weight
519.47
References & Citations
[1]Hasegawa M, et al. Discovery of novel benzimidazoles as potent inhibitors of TIE-2 and VEGFR-2 tyrosine kinase receptors. J Med Chem. 2007 Sep 6;50(18):4453-70.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156635/TIE-2-VEGFR-2-kinase-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156635/
Clinical Information
No Development Reported
CAS Number
433224-09-0
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