Ionizable lipid-1 (hydrochloride)

Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure[1].

Product Specifications

UNSPSC

12352200

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ionizable-lipid-1-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.O=C(CCCCCCCCC(CCCCCCCCC(OC(CCCCCC)CCCCCC)=O)N(CCCN(C)C)C(CCCCCCC)=O)OC(CCCCCC)CCCCCC

Molecular Formula

C58H115ClN2O5

Molecular Weight

956.00

References & Citations

[1]Thomas D Madden, et al. Lamellar lipid nanoparticles. Patent WO2019089828A1.|[2]Ramaswamy S, et al., Systemic delivery of factor IX messenger RNA for protein replacement therapy. Proc Natl Acad Sci U S A. 2017 Mar 7;114 (10) :E1941-E1950.

Shipping Conditions

Room temperature

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Curated Selection

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