Wnt-C59 (GMP)

Wnt-C59 (C59) GMP is a GMP grade Wnt-C59 (HY-15659) . GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC50 of 74 pM.

Product Specifications

CAS Number

[1243243-89-1]

Product Name Alternative

C59 (GMP)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Porcupine; Wnt

Type

GMP Small Molecules

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/wnt-c59-gmp.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=C(C2=CC=CN=C2)C=C1)CC3=CC=C(C4=CC(C)=NC=C4)C=C3

Molecular Formula

C25H21N3O

Molecular Weight

379.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Proffitt KD, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013 Jan 15;73 (2) :502-7.|[2]Cheng Y, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015 Jun 10;6 (16) :14428-39.