ROCK-IN-9
ROCK-IN-9 (Compound T345) is a ROCK inhibitor. ROCK-IN-9 shows cytotoxicity in HepG2 cell, with an IC50 of 40.8 μM. ROCK-IN-9 has good pharmacokinetic properties in mice, and shows high in vivo exposure and oral bioavailability at lower doses[1].
Product Specifications
CAS Number
[2643334-76-1]
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rock-in-9.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2=C(CC1)C=C(C3=CNN=C3N)C(F)=C2)NCC4=CC(OC)=CC=C4
Molecular Formula
C20H20FN5O2
Molecular Weight
381.40
References & Citations
[1]Li, Jinping, et al. Rock inhibitor, preparation method therefor and use thereof. WO2021093795.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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