DGKα-IN-4
DGKα-IN-4 (example 432) is a DGKα inhibitor with the IC50 of 0.1 nM, extracted from patent WO2021105117. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-3 has the potential for cancer and immunology study.
Product Specifications
CAS Number
2648723-43-5
UNSPSC
12352005
Target
DGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dgkα-in-4.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC2=C(N(C)C(C(C#N)=C2N3CCC(C)(CC3)C4=NC5=C(O4)C=CC(C)=C5)=O)C=C1OC6COCC6
Molecular Formula
C30H29N5O4
Molecular Weight
523.58
References & Citations
[1]Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105117.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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