DGKα-IN-3
DGKα-IN-3 (example 25) is a DGKα inhibitor with the IC50 of 283 nM, extracted from patent WO2021105115. DGKα-IN-2 significantly enhances the anti-tumor effect of anti-PD-1 by increasing the proliferation and function of T cells. DGKα-IN-2 has the potential for cancer and immunology study.
Product Specifications
CAS Number
[2648418-86-2]
UNSPSC
12352005
Target
DGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dgkα-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(N2CCC3(CC2)CN(CC3)C4=CC=C(C=C4)OC(F)(F)F)C5=C(C=CC=C5)N(C)C1=O)N
Molecular Formula
C26H27F3N4O3
Molecular Weight
500.51
References & Citations
[1]Schmees, Norbert, et al. Preparation of substituted aminoquinolones as DGKα inhibitors for immune activation. WO2021105115.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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