KRAS G12C inhibitor 61
KRAS G12C inhibitor 61 (Example 3) inhibits phospho-ERK 1/2 in MIA PaCa-2 cells with an IC50 value of 9 nM. KRAS G12C inhibitor 61 can be used for research of pancreatic, colorectal, and lung cancers[1].
Product Specifications
CAS Number
2300967-40-0
UNSPSC
12352005
Target
ERK; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-61.html
Solubility
10 mM in DMSO
Smiles
O=C1N=C(N2[C@@H](C)CN([C@H](C)C2)C(C=C)=O)C3=C(N1C4=C(C)C=CN=C4C(C)C)N=C(C5=C(N)C=CC=C5F)C(Cl)=C3
Molecular Formula
C31H33ClFN7O2
Molecular Weight
590.09
References & Citations
[1]Brian Alan Lanman, et al. Inhibitors of kras g12c and methods of using the same. Patent. WO2019051291.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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