5-HT2C agonist-3 (free base)

5-HT2C agonist-3 ((+) -19) free base is a selective 5-HT2C agonist (EC50: 24 nM, Ki: 78 nM) . 5-HT2C agonist-3 free base has antipsychotic drug-like activity. 5-HT2C agonist-3 free base blocks Amphetamine-induced hyperactivity[1].

Product Specifications

CAS Number

[2104810-17-3]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-ht2c-agonist-3-free-base.html

Solubility

10 mM in DMSO

Smiles

COC(C=CC=C1)=C1CNC[C@@H]2[C@@H](C3=C(C=CC(F)=C3)OC)C2

Molecular Formula

C19H22FNO2

Molecular Weight

315.38

References & Citations

[1]Guiping Zhang, et al. Discovery of N-Substituted (2-Phenylcyclopropyl) methylamines as Functionally Selective Serotonin 2C Receptor Agonists for Potential Use as Antipsychotic Medications. J. Med. Chem. 2017, 60, 14, 6273–6288.