αvβ1 integrin-IN-2

αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC50s of 0.9 nM, and 33 nM, respectively. αvβ1 integrin-IN-2 also inhibits other integrins with, , IC50s of 380 nM (ανβ3), 280 nM (ανβ5), 230 nM (ανβ6), 87 nM (ανβ8), respectively, in SPRA assay[1].

Product Specifications

CAS Number

[2234874-68-9]

UNSPSC

12352005

Target

Integrin

Type

Reference compound

Related Pathways

Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/αvβ1-integrin-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(CC(CC1=NN(C)C(OCCC2=CC=C3C(N2)=NCCC3)=C1)C4=CC(C(C)(C)C)=CC=C4OC)O

Molecular Formula

C29H38N4O4

Molecular Weight

506.64

References & Citations

[1]Ruminski PG, et al. Preparation of ((tetrahydronaphthyridinylethoxy) pyrazolyl) butanoic acid as integrin antagonists for the treatment and prevention of diseases. World Intellectual Property Organization, WO2018132268 A1. 2018-07-19.