αvβ1 integrin-IN-2
Product Specifications
UNSPSC Description
αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of integrins ανβ1 and α5β1 with IC50s of 0.9 nM，and 33 nM，respectively. αvβ1 integrin-IN-2 also inhibits other integrins with ，，IC50s of 380 nM (ανβ3)，280 nM (ανβ5)，230 nM (ανβ6)，87 nM (ανβ8)，respectively，in SPRA assay[1].
Target Antigen
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/αvβ1-integrin-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(CC(CC1=NN(C)C(OCCC2=CC=C3C(N2)=NCCC3)=C1)C4=CC(C(C)(C)C)=CC=C4OC)O
Molecular Weight
506.64
References & Citations
[1]Ruminski PG, et al. Preparation of ((tetrahydronaphthyridinylethoxy)pyrazolyl) butanoic acid as integrin antagonists for the treatment and prevention of diseases. World Intellectual Property Organization, WO2018132268 A1. 2018-07-19.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156521/αvβ1-integrin-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156521/
Clinical Information
No Development Reported
CAS Number
2234874-68-9
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