ICMT-IN-1

ICMT-IN-1 is a potent inhibitor of ICMT with an IC50 of 1.3 nM. ICMT-IN-1 can delay senescence and stimulate late-passage HGPS cells and Zmpste24-deficient mouse fibroblasts proliferation[1].

Product Specifications

CAS Number

[1313603-22-3]

UNSPSC

12352005

Target

ICMT

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/icmt-in-1.html

Solubility

10 mM in DMSO

Smiles

CC(C)(C1)OC(C)(C)CC1(C2=CC=CC=C2)CCNC3=CC(OC)=CC=C3

Molecular Formula

C24H33NO2

Molecular Weight

367.52

References & Citations

[1]Judd WR, et al. Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) . J Med Chem. 2011 Jul 28;54 (14) :5031-47.|[2]Chen X, et al. A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells. Elife. 2021 Feb 2;10:e63284.