GSK-J5 (hydrochloride)

GSK-J5 hydrochloride is a cell-permeable ester derivative of GSK J2 (HY-15648A), inactive. GSK-J5 hydrochloride is also an isomer of GSK-J4 (HY-15648B) and often used as a negative group[1].

Product Specifications

CAS Number

[1797983-32-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Histone Demethylase; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gsk-j5-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(OCC)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC4=CC=CC=C4CC3)=C1.[H]Cl

Molecular Formula

C24H28ClN5O2

Molecular Weight

453.96

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Laurens Kruidenier, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488 (7411) :404-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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