Topoisomerase I inhibitor 10
Selected Variant
HY-156464
Size: 1 Each
Topoisomerase I inhibitor 10 (compound 13) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 10 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 27.91 μM[1].
Product Specifications
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/topoisomerase-i-inhibitor-10.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C=C1)C(C2=CN(C3=C2C=C(C=C3)Br)[C@H]4O[C@H]([C@@H]([C@@H]([C@@H]4O)O)O)CO)C5=CN(C6=C5C=C(C=C6)Br)[C@@H]7O[C@@H]([C@H]([C@H]([C@H]7O)O)O)CO
Molecular Formula
C35H35Br2FN2O10
Molecular Weight
822.47
References & Citations
[1]Kour P, et al. Design, synthesis, and biological evaluation of 3,3'-diindolylmethane N-linked glycoconjugate as a leishmanial topoisomerase IB inhibitor with reduced cytotoxicity. RSC Med Chem. 2023;14 (10) :2100-2114. Published 2023 Aug 30.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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