EGFR-IN-90
EGFR-IN-90 (compound 34) is an orally active EGFR inhibitor. EGFR-IN-90 shows inhibitory activity against EGFRL858R/T790M/C797S with an IC50 of 5.1 nM and inhibits the proliferation of the H1975-TM cell line harboring EGFRL858R/T790M/C797S with an IC50 of 0.05 μM. EGFR-IN-90 and inhibits tumor growth in the H1975-TM xenograft tumor model[1].
Product Specifications
CAS Number
[3008611-00-2]
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-90.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C=C1)C2=C(SC(C3CCN(CC3)S(=O)(CC)=O)=N2)C4=CC=NC(NC5=CC=C6N(C=CC6=C5)CCN(C)C)=N4
Molecular Formula
C32H36FN7O2S2
Molecular Weight
633.80
References & Citations
[1]Zhu Y, et al. Discovery of Novel Fourth-Generation EGFR Inhibitors to Overcome C797S-Mediated Resistance. J Med Chem. 2023;66 (21) :14633-14652.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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